Publisher Correction: Examining a Thermodynamic Order Parameter of Protein Folding
نویسندگان
چکیده
منابع مشابه
Thermodynamic Principle Revisited: Theory of Protein Folding
Anfinsen’s thermodynamic hypothesis is reviewed and misunderstandings are clarified. It really should be called the thermodynamic principle of protein folding. Energy landscape is really just the mathematical graph of the Gibbs free energy function ( ) X; , N G U E , a very high dimensional hyper surface. Without knowing it any picture of the Gibbs free energy landscape has no theoretical base,...
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At the time of publication, the ancestral sequence data from this paper had not been deposited. The ancestral sequences shown in S2B Fig. are now available in GenBank (KP271037—KP271043). An easily accessible sequence alignment file for S2B Fig. is now also available (S1 File). an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestri...
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Two different dynamical-parameter algortihms are discussed, simulated tempering and the multisequence method. Using simulated tempering, the folding properties of 300 random sequences in a simple off-lattice model with only two amino-acid types, hydrophobic and hydrophilic, are investigated. A careful statistical analysis shows that the hydrophobic monomers are anticorrelated along the chains f...
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The views on protein folding have evolved from simple force-driven folding (3), i.e., the sum of many different small interactions (such as van der Waals interactions, hydrophobic interactions, hydrogen bonds, electrostatic interactions and ion pairs), to complex, free energy-driven “folding funnel” model (4) based on the energy landscape theory of protein folding (5). The latter is essentially...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-26490-6